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Fifty patients with RH and/or CKD were enrolled in a single-centre prospective study. Blood pressure (BP), 24-h ambulatory blood pressure (BP) measurements and kidney function (cystatin C) were assessed. At baseline, 50% of the patients had stage 3 CKD and 22% stage 4 CKD. Forty-six patients (92%) completed the follow-up. The treatment of RH included: a single RFA session in 20 patients, a mean of 2.0 sessions in 5 patients, dual RFA in 22 patients and triple RFA in 3 patients. Seventy-two per cent of the patients had RH and CKD. During the follow-up period, there was a significant reduction in BP with a BP decrease at 6 months of 19.7% systolic and 15.6% diastolic and a further decrease at 12 months (18.6% systolic and 14.5% diastolic). Kidney function improved in 33% of the patients; 17% of the patients showed an improvement in kidney function only and 26% showed an improvement in kidney function and BP. No major complications were recorded. 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